8OHP

Structure of the Fmoc-Tau-PAM4 Type 3 amyloid fibril

Summary for 8OHP

Entry DOI	10.2210/pdb8ohp/pdb
Related	8oh2 8ohi
EMDB information	16883
Descriptor	Microtubule-associated protein tau (1 entity in total)
Functional Keywords	amyloid, tau, helical, cross-beta, fibril, neurodegeneration, fmoc, protein fibril
Biological source	synthetic construct
Total number of polymer chains	24
Total formula weight	39654.46
Authors	Wilkinson, M.,Louros, N.,Tsaka, G.,Ramakers, M.,Morelli, C.,Garcia, T.,Gallardo, R.U.,D'Haeyer, S.,Goossens, V.,Audenaert, D.,Thal, D.R.,Ranson, N.A.,Radford, S.E.,Rousseau, F.,Schymkowitz, J. (deposition date: 2023-03-21, release date: 2024-02-21)
Primary citation	Louros, N.,Wilkinson, M.,Tsaka, G.,Ramakers, M.,Morelli, C.,Garcia, T.,Gallardo, R.,D'Haeyer, S.,Goossens, V.,Audenaert, D.,Thal, D.R.,Mackenzie, I.R.,Rademakers, R.,Ranson, N.A.,Radford, S.E.,Rousseau, F.,Schymkowitz, J. Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15:1028-1028, 2024 Cited by PubMed: 38310108 DOI: 10.1038/s41467-024-45429-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation