8OFX

Molecular Mechanism of trypanosomal AQP2

Summary for 8OFX

Entry DOI	10.2210/pdb8ofx/pdb
EMDB information	16862
Descriptor	Aquaglyceroporin 2, [(2~{R},4~{S})-2-[4-[[4,6-bis(azanyl)-1,3,5-triazin-2-yl]amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol (2 entities in total)
Functional Keywords	aquaporin, tetramer, drug uptake, glycerol, membrane protein
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	1
Total formula weight	34012.98
Authors	Weyand, S.N.,Matusevicius, M.,Yamashita, K. (deposition date: 2023-03-17, release date: 2024-10-02, Last modification date: 2025-10-22)
Primary citation	Matusevicius, M.,Corey, R.A.,Gragera, M.,Yamashita, K.,Sprenger, T.,Ungogo, M.A.,Blaza, J.N.,Castro-Hartmann, P.,Chirgadze, D.Y.,Chaitanya Vedithi, S.,Afanasyev, P.,Melero, R.,Warshamanage, R.,Gusach, A.,Carazo, J.M.,Carrington, M.,Blundell, T.L.,Murshudov, G.,Stansfeld, P.,Sansom, M.,de Koning, H.P.,Tate, C.G.,Weyand, S.N. Insights from aquaporin structures into drug-resistant sleeping sickness Elife, 2025 Cited by DOI: 10.7554/elife.107460.1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation