8OEP

Crystal structure of the PTPN3 PDZ domain bound to the HPV18 E6 oncoprotein C-terminal peptide

8OEP の概要

• エントリーDOI: 10.2210/pdb8oep/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 3, Protein E6, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: protein tyrosine phosphatase ptpn3, pdz domains, pdz-binding motif, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 28961.46

構造登録者

Genera, M.,Colcombet-Cazenave, B.,Croitoru, A.,Raynal, B.,Mechaly, A.,Caillet, J.,Haouz, A.,Wolff, N.,Caillet-Saguy, C. (登録日: 2023-03-11, 公開日: 2023-05-10, 最終更新日: 2024-06-19)

• 主引用文献: Genera, M.,Colcombet-Cazenave, B.,Croitoru, A.,Raynal, B.,Mechaly, A.,Caillet, J.,Haouz, A.,Wolff, N.,Caillet-Saguy, C.; Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.; Front Mol Biosci, 10:1192621-1192621, 2023; PubMed: 37200868; DOI: 10.3389/fmolb.2023.1192621

実験手法

X-RAY DIFFRACTION (1.87 Å)