8KI4
Crystal structure of human HSP90 in intermediate state
Summary for 8KI4
Entry DOI | 10.2210/pdb8ki4/pdb |
Descriptor | Heat shock protein HSP 90-alpha, 1,2-ETHANEDIOL (3 entities in total) |
Functional Keywords | hsp90, atpase, ntd, chaperone |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 54799.25 |
Authors | Xu, C.,Zhang, X.L.,Bai, F. (deposition date: 2023-08-22, release date: 2024-04-17, Last modification date: 2024-05-08) |
Primary citation | Xu, C.,Zhang, X.,Zhao, L.,Verkhivker, G.M.,Bai, F. Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies. Jacs Au, 4:1632-1645, 2024 Cited by PubMed: 38665669DOI: 10.1021/jacsau.4c00123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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