8KH5

Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS

Summary for 8KH5

• Entry DOI: 10.2210/pdb8kh5/pdb
• EMDB information: 37237
• Descriptor: Probable G-protein coupled receptor 174, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: gpcr, gs, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 134099.35

Authors

Nie, Y.,Qiu, Z.,Zheng, S.,Chen, S. (deposition date: 2023-08-21, release date: 2023-10-18)

• Primary citation: Nie, Y.,Qiu, Z.,Chen, S.,Chen, Z.,Song, X.,Ma, Y.,Huang, N.,Cyster, J.G.,Zheng, S.; Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.; Nat Commun, 14:5901-5901, 2023; PubMed: 37737235; DOI: 10.1038/s41467-023-41654-3

Experimental method

ELECTRON MICROSCOPY (2.83 Å)