8KH4

Cryo-EM structure of the GPR161-Gs complex

8KH4 の概要

• エントリーDOI: 10.2210/pdb8kh4/pdb
• EMDBエントリー: 37236
• 分子名称: G-protein coupled receptor 161, Guanine nucleotide-binding protein G(olf) subunit alpha,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• 機能のキーワード: gpcr, gs, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 135873.03

構造登録者

Nie, Y.,Qiu, Z.,Zheng, S.,Chen, S. (登録日: 2023-08-21, 公開日: 2023-10-11)

• 主引用文献: Nie, Y.,Qiu, Z.,Chen, S.,Chen, Z.,Song, X.,Ma, Y.,Huang, N.,Cyster, J.G.,Zheng, S.; Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.; Nat Commun, 14:5901-5901, 2023; PubMed: 37737235; DOI: 10.1038/s41467-023-41654-3

実験手法

ELECTRON MICROSCOPY (3.1 Å)