8KFQ

The crystal structure of EGFR(T797M/L858R) with small molecule inhibitor B6

Summary for 8KFQ

• Entry DOI: 10.2210/pdb8kfq/pdb
• Descriptor: Epidermal growth factor receptor, SULFATE ION, ~{N}-[3-[[6-chloranyl-2-[(1-ethylpyrazol-4-yl)amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide (3 entities in total)
• Functional Keywords: inhibitor, complex, kinase, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37440.74

Authors

Wu, C.,Ouyang, L. (deposition date: 2023-08-16, release date: 2024-08-21, Last modification date: 2024-10-09)

• Primary citation: Wu, C.,Ouyang, L.; Structure of EGFR(T979M/L858R) with small molecule inhibitor B6; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.22 Å)