8KFQ
The crystal structure of EGFR(T797M/L858R) with small molecule inhibitor B6
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 322 | 36910.8 | 1 | UniProt (P00533) In PDB | Homo sapiens (human) | |
2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
3 | A | ~{N}-[3-[[6-chloranyl-2-[(1-ethylpyrazol-4-yl)amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide | non-polymer | 433.9 | 1 | Chemie (VUZ) |
Sequence modifications
A: 697 - 1018 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Met 790 | Thr 790 | engineered mutation |
Arg 858 | Leu 858 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36910.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 530.0 | |
All* | Total formula weight | 37440.7 |