8KDB

Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form

Summary for 8KDB

• Entry DOI: 10.2210/pdb8kdb/pdb
• EMDB information: 37130
• Descriptor: RNA-directed RNA polymerase L, Phosphoprotein, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: dimeric polymerase, parainfluenza virus, l-p polymerase, cryo-em structure, non-segmented negative-strand rna virus, l-l dimerization, rna replication, rdrp active site, viral protein
• Biological source: Human respirovirus 3; More
• Total number of polymer chains: 7
• Total formula weight: 862719.09

Authors

Xie, J.,Wang, L.,Zhai, G.,Wu, D.,Lin, Z.,Wang, M.,Yan, X.,Gao, L.,Huang, X.,Fearns, R.,Chen, S. (deposition date: 2023-08-09, release date: 2024-04-24)

• Primary citation: Xie, J.,Ouizougun-Oubari, M.,Wang, L.,Zhai, G.,Wu, D.,Lin, Z.,Wang, M.,Ludeke, B.,Yan, X.,Nilsson, T.,Gao, L.,Huang, X.,Fearns, R.,Chen, S.; Structural basis for dimerization of a paramyxovirus polymerase complex.; Nat Commun, 15:3163-3163, 2024; PubMed: 38605025; DOI: 10.1038/s41467-024-47470-7

Experimental method

ELECTRON MICROSCOPY (2.7 Å)