8KCT
Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
Summary for 8KCT
| Entry DOI | 10.2210/pdb8kct/pdb |
| EMDB information | 37109 |
| Descriptor | Nicastrin, (2S)-2-[[(2S)-6,8-bis(fluoranyl)-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methyl-propan-2-yl]imidazol-4-yl]pentanamide, Gamma-secretase subunit APH-1A, ... (10 entities in total) |
| Functional Keywords | intramembrane protease, gamma-secretase, gamma-secretase inhibitor, membrane protein, membrane protein-hydrolase complex |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 178982.10 |
| Authors | |
| Primary citation | Guo, X.,Li, H.,Kai, U.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published, |
| Experimental method |
Structure validation
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