8K8B
Solution structure of a hairpin RNA with the UUCGA loop
Summary for 8K8B
| Entry DOI | 10.2210/pdb8k8b/pdb |
| NMR Information | BMRB: 36587 |
| Descriptor | RNA (5'-R(*GP*GP*AP*UP*CP*CP*UP*UP*UP*CP*GP*AP*GP*GP*GP*AP*UP*CP*C)-3') (1 entity in total) |
| Functional Keywords | penta loop, uucg loop, rna |
| Biological source | Mus musculus |
| Total number of polymer chains | 1 |
| Total formula weight | 6070.63 |
| Authors | |
| Primary citation | Ichijo, R.,Kawai, G. NMR analysis of a loop-bulge structure of UUCGA pentaloop. Biochem.Biophys.Res.Commun., 691:149327-149327, 2024 Cited by PubMed Abstract: Although structures of many RNA loops, such as GNRA and UNCG tetraloops, were well known, it is still possible to find more RNA structures. In the present study, solution structure of an RNA fragment having UUCGA pentaloop was analyzed by NMR spectroscopy. It was found that the UUCG tetraloop is formed and the adenosine residue at the 3' side of the tetraloop is bulged out. The characteristic motif of the loop-bulge structure has also been found in other RNAs including CUUGU and CUGGC pentaloops. Along with the recently found T-hairpin structure with a UUUGAUU loop, in which UUUGA pentaloop and UU bulge are formed, the loop-bulge structures can be categorized as an RNA motif and it may be called as the integrated structure loop, I-loop. PubMed: 38039839DOI: 10.1016/j.bbrc.2023.149327 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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