8K73

Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((1-(phenylsulfonyl)pyrrolidine-3-carbonyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid

8K73 の概要

• エントリーDOI: 10.2210/pdb8k73/pdb
• 分子名称: Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: factor-inhibiting hypoxia-inducible factor, fih, 2og dependent dioxygenase, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42122.24

構造登録者

Nakashima, Y.,Corner, T.P.,Teo, R.Z.R.,Brewitz, L.,Schofield, C.J. (登録日: 2023-07-26, 公開日: 2023-12-13)

• 主引用文献: Corner, T.P.,Teo, R.Z.R.,Wu, Y.,Salah, E.,Nakashima, Y.,Fiorini, G.,Tumber, A.,Brasnett, A.,Holt-Martyn, J.P.,Figg Jr., W.D.,Zhang, X.,Brewitz, L.,Schofield, C.J.; Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha.; Chem Sci, 14:12098-12120, 2023; PubMed: 37969593; DOI: 10.1039/d3sc04253g

実験手法

X-RAY DIFFRACTION (2.02 Å)