8K4Z

Crystal structure of human MMP-7 in complex with inhibitor

8K4Z の概要

• エントリーDOI: 10.2210/pdb8k4z/pdb
• 分子名称: Matrilysin, Inhibitor, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: matrilysin, matrin, matrix metalloproteinase-7, pump-1 protease, uterine metalloproteinase, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20545.28

構造登録者

Kamitani, M.,Mima, M.,Oka, Y. (登録日: 2023-07-20, 公開日: 2024-04-17)

• 主引用文献: Oka, Y.,Abe-Sato, K.,Tabuse, H.,Yasukawa, Y.,Yahara, T.,Nishimoto, T.,Kamitani, M.,Fukunaga, T.,Ochiai, N.,Kumasaka-Abe, T.,Hitaka, K.,Gunji, E.,Ohara, H.,Takeda, T.,Kojima, N.,Asami, T.; Discovery of TP0628103: A Selective MMP-7 Inhibitor Based on the Mitigation of OATP Substrate Recognition through Isoelectric Point Shift Strategy; To Be Published,

実験手法

X-RAY DIFFRACTION (1.7 Å)