8JZX
SLC15A4 inhibitor complex
Summary for 8JZX
Entry DOI | 10.2210/pdb8jzx/pdb |
EMDB information | 36754 |
Descriptor | lysosomal transporter,ALFA tag,lysosomal transporter, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... (4 entities in total) |
Functional Keywords | endolysosomal transporter, protein transport-inhibitor complex, protein transport/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 127400.66 |
Authors | Zhang, S.S.,Chen, X.D.,Xie, M. (deposition date: 2023-07-06, release date: 2023-09-27, Last modification date: 2023-12-13) |
Primary citation | Boeszoermenyi, A.,Bernaleau, L.,Chen, X.,Kartnig, F.,Xie, M.,Zhang, H.,Zhang, S.,Delacretaz, M.,Koren, A.,Hopp, A.K.,Dvorak, V.,Kubicek, S.,Aletaha, D.,Yang, M.,Rebsamen, M.,Heinz, L.X.,Superti-Furga, G. A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun, 14:6626-6626, 2023 Cited by PubMed: 37863876DOI: 10.1038/s41467-023-42070-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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