8JZ7
Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein
Summary for 8JZ7
Entry DOI | 10.2210/pdb8jz7/pdb |
EMDB information | 36736 36737 36738 |
Descriptor | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (6 entities in total) |
Functional Keywords | complex, agonist, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 162474.24 |
Authors | Zhao, C.,Tian, X.W.,Liu, Y.,Cheng, L.,Yan, W.,Shao, Z.H. (deposition date: 2023-07-04, release date: 2023-10-04) |
Primary citation | Cheng, L.,Sun, S.,Wang, H.,Zhao, C.,Tian, X.,Liu, Y.,Fu, P.,Shao, Z.,Chai, R.,Yan, W. Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2. Signal Transduct Target Ther, 8:364-364, 2023 Cited by PubMed: 37743365DOI: 10.1038/s41392-023-01625-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
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