8JY6

Structure of TbAQP2 in complex with anti-trypanosomatid drug melarsoprol

Summary for 8JY6

Entry DOI	10.2210/pdb8jy6/pdb
EMDB information	36721
Descriptor	Aquaglyceroporin 2, [(4~{R})-2-[4-[[4,6-bis(azanyl)-1,3,5-triazin-2-yl]amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol (2 entities in total)
Functional Keywords	aquaporin, membrane protein
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	4
Total formula weight	148697.01
Authors	Chen, W.,Wang, C. (deposition date: 2023-07-03, release date: 2024-05-29)
Primary citation	Chen, W.,Zou, R.,Mei, Y.,Li, J.,Xuan, Y.,Cui, B.,Zou, J.,Wang, J.,Lin, S.,Zhang, Z.,Wang, C. Structural insights into drug transport by an aquaglyceroporin. Nat Commun, 15:3985-3985, 2024 Cited by PubMed: 38734677 DOI: 10.1038/s41467-024-48445-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation