8JVE

Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer

8JVE の概要

• エントリーDOI: 10.2210/pdb8jve/pdb
• 分子名称: Ubiquitin-conjugating enzyme E2 T, 1-(3-methoxyphenyl)-1,2,3,4-tetrazole, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: ube2t, drug discovery, covalent inhibitor, fanconi anemia, ligase-inhibitor complex, ligase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18068.84

構造登録者

Anantharajan, J.,Baburajendran, N. (登録日: 2023-06-28, 公開日: 2023-11-29)

• 主引用文献: Anantharajan, J.,Tan, Q.W.,Fulwood, J.,Sifang, W.,Huang, Q.,Ng, H.Q.,Koh, X.,Xu, W.,Cherian, J.,Baburajendran, N.,Kang, C.,Ke, Z.; Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer.; Biochem.Biophys.Res.Commun., 689:149238-149238, 2023; PubMed: 37979329; DOI: 10.1016/j.bbrc.2023.149238

実験手法

X-RAY DIFFRACTION (1.76 Å)