8JT8
Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179
Summary for 8JT8
Entry DOI | 10.2210/pdb8jt8/pdb |
Descriptor | 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, MAGNESIUM ION, 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, ... (7 entities in total) |
Functional Keywords | gpcr, serotonin receptor, antipsychotic, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 46079.44 |
Authors | |
Primary citation | Chen, Z.,Yu, J.,Wang, H.,Xu, P.,Fan, L.,Sun, F.,Huang, S.,Zhang, P.,Huang, H.,Gu, S.,Zhang, B.,Zhou, Y.,Wan, X.,Pei, G.,Xu, H.E.,Cheng, J.,Wang, S. Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187:2194-2208.e22, 2024 Cited by PubMed: 38552625DOI: 10.1016/j.cell.2024.02.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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