8JT6

5-HT1A-Gi in complex with compound (R)-IHCH-7179

Summary for 8JT6

Entry DOI	10.2210/pdb8jt6/pdb
EMDB information	36634
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ScFv16, ... (9 entities in total)
Functional Keywords	serotonin receptor, 5-ht1ar, gi-protein, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	178793.33
Authors	Chen, Z.,Xu, P.,Huang, S.,Xu, H.E.,Wang, S. (deposition date: 2023-06-21, release date: 2024-02-28, Last modification date: 2024-05-08)
Primary citation	Chen, Z.,Yu, J.,Wang, H.,Xu, P.,Fan, L.,Sun, F.,Huang, S.,Zhang, P.,Huang, H.,Gu, S.,Zhang, B.,Zhou, Y.,Wan, X.,Pei, G.,Xu, H.E.,Cheng, J.,Wang, S. Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187:2194-2208.e22, 2024 Cited by PubMed: 38552625 DOI: 10.1016/j.cell.2024.02.034 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation