8JRL

Crystal structure of P450 TleB with an indole alkaloid

Summary for 8JRL

• Entry DOI: 10.2210/pdb8jrl/pdb
• Descriptor: Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE, (2~{S})-~{N}-[(2~{S})-1-(4-fluoranyl-1~{H}-indol-3-yl)-3-oxidanyl-propan-2-yl]-3-methyl-2-sulfanyl-butanamide, ... (4 entities in total)
• Functional Keywords: cytochrome p450, heme binding, iron ion binding, oxidoreductase
• Biological source: Streptomyces blastmyceticus
• Total number of polymer chains: 1
• Total formula weight: 47961.46

Authors

Wang, J.,Yan, W.P. (deposition date: 2023-06-17, release date: 2024-04-17)

• Primary citation: Ge, X.Y.,Long, Y.,Wang, J.,Gu, B.,Yang, Z.X.,Feng, Y.Y.,Zheng, S.,Li, Y.Y.,Yan, W.P.,Song, H.; Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy. and protein engineering.; Sci China Chem, 66:3232-3241, 2023; DOI: 10.1007/s11426-023-1755-4

Experimental method

X-RAY DIFFRACTION (2.07 Å)