8JN9
Crystal structure of c-Src in complex with covalent inhibitor LW-Srci-8
Summary for 8JN9
Entry DOI | 10.2210/pdb8jn9/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-[(1R)-1-[3,5-bis(fluoranyl)phenyl]-2-(cyclopentylamino)-2-oxidanylidene-ethyl]-N-cyclopropyl-prop-2-enamide (3 entities in total) |
Functional Keywords | src kinase, covalent inhibitor, auto-phosphorylation site, oncoprotein-inhibitor complex, oncoprotein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 60334.94 |
Authors | Zhang, H.M.,Luo, C. (deposition date: 2023-06-06, release date: 2024-06-12, Last modification date: 2024-10-09) |
Primary citation | Zhang, H.M.,Luo, C. The crystal structure of c-Src in complex with covalent inhibitor LW-Srci-8 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.724 Å) |
Structure validation
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