8JLE

Cryo-EM structure of SV2A LD4 in complex with BoNT/A2 Hc in the SV2A-levetiracetam-BoNT/A2 Hc complex

Summary for 8JLE

• Entry DOI: 10.2210/pdb8jle/pdb
• EMDB information: 36394
• Descriptor: Synaptic vesicle glycoprotein 2A, Botulinum neurotoxin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: synaptic vesicle, epilepsy, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 63266.39

Authors

Yamagata, A. (deposition date: 2023-06-02, release date: 2024-05-01, Last modification date: 2024-05-08)

• Primary citation: Yamagata, A.,Ito, K.,Suzuki, T.,Dohmae, N.,Terada, T.,Shirouzu, M.; Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.; Nat Commun, 15:3027-3027, 2024; PubMed: 38637505; DOI: 10.1038/s41467-024-47322-4

Experimental method

ELECTRON MICROSCOPY (2.82 Å)