8JF5

Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440

8JF5 の概要

• エントリーDOI: 10.2210/pdb8jf5/pdb
• 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: histone demethylase, flavoprotein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90660.24

構造登録者

Fukushima, H.,Machida, T.,Yamashita, S.,Suzuki, T. (登録日: 2023-05-17, 公開日: 2024-05-22)

• 主引用文献: Machida, T.,Tsukioka, S.,Gong, Y.,Onodera, A.,Nakayama, A.,Hashimoto, N.,Ohkubo, S.,Tanaka, T.; TAS1440, a histone H3 competitive LSD1 inhibitor, activates both TGF-beta and notch signaling pathways via INSM1 dissociation in neuroendocrine small cell lung cancer; To Be Published,

実験手法

X-RAY DIFFRACTION (3.2 Å)