8J8F

Monkeypox virus DNA replication holoenzyme F8, A22 and E4 in complex with a DNA duplex and dCTP

Summary for 8J8F

• Entry DOI: 10.2210/pdb8j8f/pdb
• Related: 8HDZ 8HOY 8HPA 8J86
• EMDB information: 36068
• Descriptor: DNA polymerase, E4R, DNA polymerase processivity factor component A20, ... (7 entities in total)
• Functional Keywords: monkeypox virus, dna replication holoenzyme, dna replication machinery, dna polymerase, b-family dna polymerase, uracil-dna glycosylase, mpxv, orthopoxvirus, poxviridae, dna processivity factor, viral protein
• Biological source: Monkeypox virus; More
• Total number of polymer chains: 5
• Total formula weight: 216760.49

Authors

Xu, Y.,Wu, Y.,Wu, X.,Zhang, Y.,Yang, Y.,Li, D.,Yang, B.,Gao, K.,Zhang, Z.,Dong, C. (deposition date: 2023-05-01, release date: 2024-05-08, Last modification date: 2024-06-05)

• Primary citation: Xu, Y.,Wu, Y.,Wu, X.,Zhang, Y.,Yang, Y.,Li, D.,Yang, B.,Gao, K.,Zhang, Z.,Dong, C.; Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir.; Int.J.Biol.Macromol., 270:132231-132231, 2024; PubMed: 38735603; DOI: 10.1016/j.ijbiomac.2024.132231

Experimental method

ELECTRON MICROSCOPY (2.98 Å)