8J85

Cryo-EM structure of ochratoxin A-detoxifying amidohydrolase ADH3 mutant S88E in complex with ochratoxin A

Summary for 8J85

• Entry DOI: 10.2210/pdb8j85/pdb
• EMDB information: 36060
• Descriptor: Amidohydrolase family protein, ZINC ION, (2~{S})-2-[[(3~{R})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid (3 entities in total)
• Functional Keywords: amidohydrolase, octamer, ochratoxin a degradtion, cryo-em structure, hydrolase
• Biological source: Stenotrophomonas acidaminiphila
• Total number of polymer chains: 8
• Total formula weight: 370346.39

Authors

Dai, L.H.,Niu, D.,Huang, J.-W.,Li, X.,Shen, P.P.,Li, H.,Hu, Y.M.,Yang, Y.,Chen, C.-C.,Guo, R.-T. (deposition date: 2023-04-30, release date: 2023-08-30, Last modification date: 2023-11-15)

• Primary citation: Dai, L.,Niu, D.,Huang, J.W.,Li, X.,Shen, P.,Li, H.,Xie, Z.,Min, J.,Hu, Y.,Yang, Y.,Guo, R.T.,Chen, C.C.; Cryo-EM structure and rational engineering of a superefficient ochratoxin A-detoxifying amidohydrolase.; J Hazard Mater, 458:131836-131836, 2023; PubMed: 37331057; DOI: 10.1016/j.jhazmat.2023.131836

Experimental method

ELECTRON MICROSCOPY (2.7 Å)