8J80

Cryo-EM structure of hZnT7-Fab complex in zinc state 1, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-unbound conformation

8J80 の概要

• エントリーDOI: 10.2210/pdb8j80/pdb
• EMDBエントリー: 36055
• 分子名称: Zinc transporter 7, Light chain of YN7114-08 Fab, Heavy chain of YN7114-08 Fab, ... (4 entities in total)
• 機能のキーワード: zinc, proton, transporter, golgi apparatus, metal transporter, histidine-rich loop, metal transport
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 184303.31

構造登録者

Han, B.B.,Inaba, K.,Watanabe, S. (登録日: 2023-04-28, 公開日: 2023-09-20)

• 主引用文献: Bui, H.B.,Watanabe, S.,Nomura, N.,Liu, K.,Uemura, T.,Inoue, M.,Tsutsumi, A.,Fujita, H.,Kinoshita, K.,Kato, Y.,Iwata, S.,Kikkawa, M.,Inaba, K.; Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.; Nat Commun, 14:4770-4770, 2023; PubMed: 37553324; DOI: 10.1038/s41467-023-40521-5

実験手法

ELECTRON MICROSCOPY (2.68 Å)