8J6Q

Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex

8J6Q の概要

• エントリーDOI: 10.2210/pdb8j6q/pdb
• EMDBエントリー: 36011
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (10 entities in total)
• 機能のキーワード: hydroxycarboxylic acid receptor, 3-hb, class a gpcr, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 146390.70

構造登録者

Mao, C.,Gao, M.,Zang, S.,Zhu, Y.,Ma, X.,Zhang, Y. (登録日: 2023-04-26, 公開日: 2023-12-06)

• 主引用文献: Mao, C.,Gao, M.,Zang, S.K.,Zhu, Y.,Shen, D.D.,Chen, L.N.,Yang, L.,Wang, Z.,Zhang, H.,Wang, W.W.,Shen, Q.,Lu, Y.,Ma, X.,Zhang, Y.; Orthosteric and allosteric modulation of human HCAR2 signaling complex.; Nat Commun, 14:7620-7620, 2023; PubMed: 37993467; DOI: 10.1038/s41467-023-43537-z

実験手法

ELECTRON MICROSCOPY (2.6 Å)