8J5G

Crystal structure of kinase AbmG in complex with 4'-hydroxy-4'-thiocytidine 5'-diphosphate

Summary for 8J5G

Entry DOI	10.2210/pdb8j5g/pdb
Descriptor	Deoxyadenosine/deoxycytidine kinase, [(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-2-(hydroxymethyl)-3,4-bis(oxidanyl)thiolan-2-yl] phosphono hydrogen phosphate (3 entities in total)
Functional Keywords	albomycin, biosynthesis, transferase
Biological source	Streptomyces sp. ATCC 700974
Total number of polymer chains	1
Total formula weight	27839.15
Authors	Ushimaru, R.,Mori, T.,Liu, H.-w.,Abe, I. (deposition date: 2023-04-22, release date: 2024-04-24, Last modification date: 2025-11-05)
Primary citation	Zheng, Z.,Ushimaru, R.,Mori, T.,Ruszczycky, M.W.,Abe, I.,Liu, H.W. Biosynthesis of the Thiofuranose Core in Albomycin Requires a Versatile Enzyme AbmG That Catalyzes Net Dehydration via Cryptic Phosphorylation J.Am.Chem.Soc., 147:34143-34149, 2025 Cited by DOI: 10.1021/jacs.5c12827 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation