8J47

CryoEM Structure of 40-Residue Arctic (E22G) Beta-Amyloid Fibril Derived by Co-Analysis with Solid-State NMR | E22G Abeta40

Summary for 8J47

• Entry DOI: 10.2210/pdb8j47/pdb
• EMDB information: 35972
• Descriptor: E22G Amyloid-beta (1 entity in total)
• Functional Keywords: amyloid, alzheimer's, familial alzheimer's, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 42637.90

Authors

Tehrani, M.J.,Matsuda, I.,Yamagata, A.,Matsunaga, T.,Sato, M.,Toyooka, K.,Shirouzu, M.,Ishii, Y.,Kodama, Y.,McElheny, D.,Kobayashi, N. (deposition date: 2023-04-19, release date: 2024-09-11)

• Primary citation: Tehrani, M.J.,Matsuda, I.,Yamagata, A.,Kodama, Y.,Matsunaga, T.,Sato, M.,Toyooka, K.,McElheny, D.,Kobayashi, N.,Shirouzu, M.,Ishii, Y.; E22G A beta 40 fibril structure and kinetics illuminate how A beta 40 rather than A beta 42 triggers familial Alzheimer's; Nat Commun, 15:7045-, 2024; DOI: 10.1038/s41467-024-51294-w

Experimental method

ELECTRON MICROSCOPY (2.5 Å)