8J47
CryoEM Structure of 40-Residue Arctic (E22G) Beta-Amyloid Fibril Derived by Co-Analysis with Solid-State NMR | E22G Abeta40
Summary for 8J47
Entry DOI | 10.2210/pdb8j47/pdb |
EMDB information | 35972 |
Descriptor | E22G Amyloid-beta (1 entity in total) |
Functional Keywords | amyloid, alzheimer's, familial alzheimer's, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 10 |
Total formula weight | 42637.90 |
Authors | Tehrani, M.J.,Matsuda, I.,Yamagata, A.,Matsunaga, T.,Sato, M.,Toyooka, K.,Shirouzu, M.,Ishii, Y.,Kodama, Y.,McElheny, D.,Kobayashi, N. (deposition date: 2023-04-19, release date: 2024-09-11) |
Primary citation | Tehrani, M.J.,Matsuda, I.,Yamagata, A.,Kodama, Y.,Matsunaga, T.,Sato, M.,Toyooka, K.,McElheny, D.,Kobayashi, N.,Shirouzu, M.,Ishii, Y. E22G A beta 40 fibril structure and kinetics illuminate how A beta 40 rather than A beta 42 triggers familial Alzheimer's Nat Commun, 15:7045-, 2024 Cited by DOI: 10.1038/s41467-024-51294-wPDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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