8ITM
Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein
Summary for 8ITM
Entry DOI | 10.2210/pdb8itm/pdb |
EMDB information | 35707 |
Descriptor | Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total) |
Functional Keywords | cryo-electron microscopy; g protein-coupled receptor; splice variant; receptor activation., structural protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 149059.27 |
Authors | Zhao, F.H.,Hang, K.N.,Zhou, Q.T.,Shao, L.J.,Li, H.,Li, W.Z.,Lin, S.,Dai, A.T.,Cai, X.Q.,Liu, Y.Y.,Xu, Y.N.,Feng, W.B.,Yang, D.H.,Wang, M.W. (deposition date: 2023-03-22, release date: 2023-10-18) |
Primary citation | Zhao, F.,Hang, K.,Zhou, Q.,Shao, L.,Li, H.,Li, W.,Lin, S.,Dai, A.,Cai, X.,Liu, Y.,Xu, Y.,Feng, W.,Yang, D.,Wang, M.W. Molecular basis of signal transduction mediated by the human GIPR splice variants. Proc.Natl.Acad.Sci.USA, 120:e2306145120-e2306145120, 2023 Cited by PubMed: 37792509DOI: 10.1073/pnas.2306145120 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.13 Å) |
Structure validation
Download full validation report