8IQ6
Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex
Summary for 8IQ6
Entry DOI | 10.2210/pdb8iq6/pdb |
EMDB information | 35658 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | gpcr, complex, prostaglandin receptor, agonist, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 133434.36 |
Authors | |
Primary citation | Lv, X.,Gao, K.,Nie, J.,Zhang, X.,Zhang, S.,Ren, Y.,Sun, X.,Li, Q.,Huang, J.,Liu, L.,Zhang, X.,Zhang, W.,Liu, X. Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity. Nat Commun, 14:8136-8136, 2023 Cited by PubMed: 38065938DOI: 10.1038/s41467-023-43922-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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