8IMG

Human cGAS catalytic domain bound with C20

Summary for 8IMG

• Entry DOI: 10.2210/pdb8img/pdb
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION, 2-[2-hydroxy-2-oxoethyl-[3-(7-methoxy-4-methyl-2-oxidanylidene-chromen-3-yl)propanoyl]amino]ethanoic acid, ... (4 entities in total)
• Functional Keywords: cgas, inhibitor, c20, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86026.70

Authors

Zhao, W.F.,Li, J.M.,Xu, Y.C. (deposition date: 2023-03-06, release date: 2024-01-03)

• Primary citation: Li, J.,Xiong, M.,Liu, J.,Zhang, F.,Li, M.,Zhao, W.,Xu, Y.; Discovery of novel cGAS inhibitors based on natural flavonoids.; Bioorg.Chem., 140:106802-106802, 2023; PubMed: 37666112; DOI: 10.1016/j.bioorg.2023.106802

Experimental method

X-RAY DIFFRACTION (1.8 Å)