8IM3

Crystal structure of human HPPD complexed with compound a10

Summary for 8IM3

• Entry DOI: 10.2210/pdb8im3/pdb
• Descriptor: 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION, [1,3-diethyl-2,2-bis(oxidanylidene)-2$l^{6},1,3-benzothiadiazol-5-yl]-(1-methyl-5-oxidanyl-pyrazol-4-yl)methanone, ... (4 entities in total)
• Functional Keywords: complex, inhibitor, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 272433.46

Authors

Dong, J.,Lin, H.-Y. (deposition date: 2023-03-05, release date: 2023-10-18, Last modification date: 2023-12-27)

• Primary citation: Dong, J.,Xiao, H.,Chen, J.N.,Zheng, B.F.,Xu, Y.L.,Chen, M.X.,Yang, W.C.,Lin, H.Y.,Yang, G.F.; Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.; Structure, 31:1604-, 2023; PubMed: 37794595; DOI: 10.1016/j.str.2023.09.005

Experimental method

X-RAY DIFFRACTION (2.78 Å)