8IJR

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine

Summary for 8IJR

• Entry DOI: 10.2210/pdb8ijr/pdb
• EMDB information: 35493
• Descriptor: Sphingomyelin synthase-related protein 1, (2S)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11Z)-octadec-11-enoate, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER (3 entities in total)
• Functional Keywords: synthase, sphingomyelin, cpe, membrane protein, lipid metabolism
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 294092.66

Authors

Hu, K.,Zhang, Q.,Chen, Y.,Yao, D.,Zhou, L.,Cao, Y. (deposition date: 2023-02-28, release date: 2024-02-28, Last modification date: 2024-07-03)

• Primary citation: Hu, K.,Zhang, Q.,Chen, Y.,Yang, J.,Xia, Y.,Rao, B.,Li, S.,Shen, Y.,Cao, M.,Lu, H.,Qin, A.,Jiang, X.C.,Yao, D.,Zhao, J.,Zhou, L.,Cao, Y.; Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.; Nat.Struct.Mol.Biol., 31:884-895, 2024; PubMed: 38388831; DOI: 10.1038/s41594-024-01237-2

Experimental method

ELECTRON MICROSCOPY (3.29 Å)