8IJR

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0002950	molecular_function	ceramide phosphoethanolamine synthase activity
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006686	biological_process	sphingomyelin biosynthetic process
A	0016020	cellular_component	membrane
A	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
A	0033188	molecular_function	sphingomyelin synthase activity
A	0046513	biological_process	ceramide biosynthetic process
A	0047493	molecular_function	ceramide cholinephosphotransferase activity
A	2000303	biological_process	regulation of ceramide biosynthetic process
B	0000139	cellular_component	Golgi membrane
B	0002950	molecular_function	ceramide phosphoethanolamine synthase activity
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006686	biological_process	sphingomyelin biosynthetic process
B	0016020	cellular_component	membrane
B	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
B	0033188	molecular_function	sphingomyelin synthase activity
B	0046513	biological_process	ceramide biosynthetic process
B	0047493	molecular_function	ceramide cholinephosphotransferase activity
B	2000303	biological_process	regulation of ceramide biosynthetic process
C	0000139	cellular_component	Golgi membrane
C	0002950	molecular_function	ceramide phosphoethanolamine synthase activity
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006686	biological_process	sphingomyelin biosynthetic process
C	0016020	cellular_component	membrane
C	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
C	0033188	molecular_function	sphingomyelin synthase activity
C	0046513	biological_process	ceramide biosynthetic process
C	0047493	molecular_function	ceramide cholinephosphotransferase activity
C	2000303	biological_process	regulation of ceramide biosynthetic process
D	0000139	cellular_component	Golgi membrane
D	0002950	molecular_function	ceramide phosphoethanolamine synthase activity
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0006686	biological_process	sphingomyelin biosynthetic process
D	0016020	cellular_component	membrane
D	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
D	0033188	molecular_function	sphingomyelin synthase activity
D	0046513	biological_process	ceramide biosynthetic process
D	0047493	molecular_function	ceramide cholinephosphotransferase activity
D	2000303	biological_process	regulation of ceramide biosynthetic process
E	0000139	cellular_component	Golgi membrane
E	0002950	molecular_function	ceramide phosphoethanolamine synthase activity
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006686	biological_process	sphingomyelin biosynthetic process
E	0016020	cellular_component	membrane
E	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
E	0033188	molecular_function	sphingomyelin synthase activity
E	0046513	biological_process	ceramide biosynthetic process
E	0047493	molecular_function	ceramide cholinephosphotransferase activity
E	2000303	biological_process	regulation of ceramide biosynthetic process
F	0000139	cellular_component	Golgi membrane
F	0002950	molecular_function	ceramide phosphoethanolamine synthase activity
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006686	biological_process	sphingomyelin biosynthetic process
F	0016020	cellular_component	membrane
F	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
F	0033188	molecular_function	sphingomyelin synthase activity
F	0046513	biological_process	ceramide biosynthetic process
F	0047493	molecular_function	ceramide cholinephosphotransferase activity
F	2000303	biological_process	regulation of ceramide biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	720
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

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Residue

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {}

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