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8IJR

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0002950molecular_functionceramide phosphoethanolamine synthase activity
A0003674molecular_functionmolecular_function
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006665biological_processsphingolipid metabolic process
A0006686biological_processsphingomyelin biosynthetic process
A0016020cellular_componentmembrane
A0016740molecular_functiontransferase activity
A0016780molecular_functionphosphotransferase activity, for other substituted phosphate groups
A0033188molecular_functionsphingomyelin synthase activity
A0046513biological_processceramide biosynthetic process
A0047493molecular_functionceramide cholinephosphotransferase activity
A1905373biological_processceramide phosphoethanolamine biosynthetic process
A2000303biological_processregulation of ceramide biosynthetic process
B0000139cellular_componentGolgi membrane
B0002950molecular_functionceramide phosphoethanolamine synthase activity
B0003674molecular_functionmolecular_function
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006665biological_processsphingolipid metabolic process
B0006686biological_processsphingomyelin biosynthetic process
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016780molecular_functionphosphotransferase activity, for other substituted phosphate groups
B0033188molecular_functionsphingomyelin synthase activity
B0046513biological_processceramide biosynthetic process
B0047493molecular_functionceramide cholinephosphotransferase activity
B1905373biological_processceramide phosphoethanolamine biosynthetic process
B2000303biological_processregulation of ceramide biosynthetic process
C0000139cellular_componentGolgi membrane
C0002950molecular_functionceramide phosphoethanolamine synthase activity
C0003674molecular_functionmolecular_function
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006665biological_processsphingolipid metabolic process
C0006686biological_processsphingomyelin biosynthetic process
C0016020cellular_componentmembrane
C0016740molecular_functiontransferase activity
C0016780molecular_functionphosphotransferase activity, for other substituted phosphate groups
C0033188molecular_functionsphingomyelin synthase activity
C0046513biological_processceramide biosynthetic process
C0047493molecular_functionceramide cholinephosphotransferase activity
C1905373biological_processceramide phosphoethanolamine biosynthetic process
C2000303biological_processregulation of ceramide biosynthetic process
D0000139cellular_componentGolgi membrane
D0002950molecular_functionceramide phosphoethanolamine synthase activity
D0003674molecular_functionmolecular_function
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006665biological_processsphingolipid metabolic process
D0006686biological_processsphingomyelin biosynthetic process
D0016020cellular_componentmembrane
D0016740molecular_functiontransferase activity
D0016780molecular_functionphosphotransferase activity, for other substituted phosphate groups
D0033188molecular_functionsphingomyelin synthase activity
D0046513biological_processceramide biosynthetic process
D0047493molecular_functionceramide cholinephosphotransferase activity
D1905373biological_processceramide phosphoethanolamine biosynthetic process
D2000303biological_processregulation of ceramide biosynthetic process
E0000139cellular_componentGolgi membrane
E0002950molecular_functionceramide phosphoethanolamine synthase activity
E0003674molecular_functionmolecular_function
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006665biological_processsphingolipid metabolic process
E0006686biological_processsphingomyelin biosynthetic process
E0016020cellular_componentmembrane
E0016740molecular_functiontransferase activity
E0016780molecular_functionphosphotransferase activity, for other substituted phosphate groups
E0033188molecular_functionsphingomyelin synthase activity
E0046513biological_processceramide biosynthetic process
E0047493molecular_functionceramide cholinephosphotransferase activity
E1905373biological_processceramide phosphoethanolamine biosynthetic process
E2000303biological_processregulation of ceramide biosynthetic process
F0000139cellular_componentGolgi membrane
F0002950molecular_functionceramide phosphoethanolamine synthase activity
F0003674molecular_functionmolecular_function
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006665biological_processsphingolipid metabolic process
F0006686biological_processsphingomyelin biosynthetic process
F0016020cellular_componentmembrane
F0016740molecular_functiontransferase activity
F0016780molecular_functionphosphotransferase activity, for other substituted phosphate groups
F0033188molecular_functionsphingomyelin synthase activity
F0046513biological_processceramide biosynthetic process
F0047493molecular_functionceramide cholinephosphotransferase activity
F1905373biological_processceramide phosphoethanolamine biosynthetic process
F2000303biological_processregulation of ceramide biosynthetic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues720
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AILE153-VAL173
BPHE277-MET297
BPHE322-HIS342
BILE347-ALA367
CILE153-VAL173
CPHE201-LEU221
CLEU232-LEU252
CPHE277-MET297
CPHE322-HIS342
CILE347-ALA367
DILE153-VAL173
APHE201-LEU221
DPHE201-LEU221
DLEU232-LEU252
DPHE277-MET297
DPHE322-HIS342
DILE347-ALA367
EILE153-VAL173
EPHE201-LEU221
ELEU232-LEU252
EPHE277-MET297
EPHE322-HIS342
ALEU232-LEU252
EILE347-ALA367
FILE153-VAL173
FPHE201-LEU221
FLEU232-LEU252
FPHE277-MET297
FPHE322-HIS342
FILE347-ALA367
APHE277-MET297
APHE322-HIS342
AILE347-ALA367
BILE153-VAL173
BPHE201-LEU221
BLEU232-LEU252

site_idSWS_FT_FI2
Number of Residues282
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AASN368-GLY415
BASN368-GLY415
CASN368-GLY415
DASN368-GLY415
EASN368-GLY415
FASN368-GLY415

site_idSWS_FT_FI3
Number of Residues12
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AHIS301
EHIS344
FHIS301
FHIS344
AHIS344
BHIS301
BHIS344
CHIS301
CHIS344
DHIS301
DHIS344
EHIS301

site_idSWS_FT_FI4
Number of Residues6
DetailsACT_SITE:
ChainResidueDetails
AASP348
BASP348
CASP348
DASP348
EASP348
FASP348

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PDB entries from 2024-07-17

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