8IHZ

FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine

8IHZ の概要

• エントリーDOI: 10.2210/pdb8ihz/pdb
• 分子名称: Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: factor-inhibiting hypoxia-inducible factor, fih, 2og dependent dioxygenase, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42154.40

構造登録者

Nakashima, Y.,Corner, T.,Zhang, X.,Schofield, C.J. (登録日: 2023-02-24, 公開日: 2024-02-28, 最終更新日: 2024-07-10)

• 主引用文献: Wu, Y.,Chen, Y.,Corner, T.,Nakashima, Y.,Salah, E.,Li, Z.,Zhang, L.,Yang, L.,Tumber, A.,Sun, Z.,Wen, Y.,Zhong, A.,Yang, F.,Li, X.,Zhang, Z.,Schofield, C.,Zhang, X.; A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.; Angew.Chem.Int.Ed.Engl., :e202410438-e202410438, 2024; PubMed: 38923188; DOI: 10.1002/anie.202410438

実験手法

X-RAY DIFFRACTION (2.22 Å)