8IHU

Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation G85R

Summary for 8IHU

• Entry DOI: 10.2210/pdb8ihu/pdb
• EMDB information: 35459
• Descriptor: Superoxide dismutase [Cu-Zn] (1 entity in total)
• Functional Keywords: amyloid fibril, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 48176.70

Authors

Wang, L.Q.,Ma, Y.Y.,Zhang, M.Y.,Yuan, H.Y.,Li, X.N.,Zhao, K.,Chen, J.,Li, D.,Wang, Z.Z.,Le, W.D.,Liu, C.,Liang, Y. (deposition date: 2023-02-23, release date: 2024-10-30)

• Primary citation: Wang, L.Q.,Ma, Y.Y.,Zhang, M.Y.,Yuan, H.Y.,Li, X.N.,Zhao, K.,Chen, J.,Li, D.,Wang, Z.Z.,Le, W.D.,Liu, C.,Liang, Y.; Amyloid fibril structures and ferroptosis activation induced by ALS-causing SOD1 mutations.; Sci Adv, 2024

Experimental method

ELECTRON MICROSCOPY (2.97 Å)