8I6D
Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with 5-Hydroxy-2,4(1H,3H)-pyrimidinedione, Form VI
Summary for 8I6D
Entry DOI | 10.2210/pdb8i6d/pdb |
Descriptor | Uracil-DNA glycosylase, 5-oxidanyl-1~{H}-pyrimidine-2,4-dione, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | dna repair, base excision repair, inhibitor-complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 2 |
Total formula weight | 52179.53 |
Authors | |
Primary citation | Kesharwani, S.,Raj, P.,Paul, A.,Roy, K.,Bhanot, A.,Mehta, A.,Gopal, A.,Varshney, U.,Gopal, B.,Sundriyal, S. Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment. Eur.J.Med.Chem., 258:115604-115604, 2023 Cited by PubMed: 37399710DOI: 10.1016/j.ejmech.2023.115604 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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