8I67

Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with 2,4-Thiazolidinedione, Form I

Summary for 8I67

• Entry DOI: 10.2210/pdb8i67/pdb
• Descriptor: Uracil-DNA glycosylase, 1,3-thiazolidine-2,4-dione, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: dna repair, base excision repair, inhibitor-complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 1
• Total formula weight: 25992.74

Authors

Raj, P.,Paul, A.,Gopal, B. (deposition date: 2023-01-27, release date: 2023-07-12)

• Primary citation: Kesharwani, S.,Raj, P.,Paul, A.,Roy, K.,Bhanot, A.,Mehta, A.,Gopal, A.,Varshney, U.,Gopal, B.,Sundriyal, S.; Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment; Eur.J.Med.Chem., 258:115604-, 2023; DOI: 10.1016/j.ejmech.2023.115604

Experimental method

X-RAY DIFFRACTION (1.72 Å)