8HXU

Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-pentylthiazole-4-carboxylic acid

Summary for 8HXU

Entry DOI	10.2210/pdb8hxu/pdb
Descriptor	Beta-lactamase class B VIM-2, ZINC ION, 2-azanyl-5-pentyl-1,3-thiazole-4-carboxylic acid, ... (5 entities in total)
Functional Keywords	beta-lactamase class b vim-2, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	2
Total formula weight	50095.11
Authors	Yan, Y.-H.,Zhu, K.-R.,Li, G.-B. (deposition date: 2023-01-05, release date: 2023-11-01)
Primary citation	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66:13746-13767, 2023 Cited by PubMed: 37791640 DOI: 10.1021/acs.jmedchem.3c01189 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.945 Å)

Structure validation