8HXC

Cryo-EM structure of MPXV M2 heptamer in complex with human B7.2

Summary for 8HXC

• Entry DOI: 10.2210/pdb8hxc/pdb
• EMDB information: 35076
• Descriptor: NFkB inhibitor, T-lymphocyte activation antigen CD86 (2 entities in total)
• Functional Keywords: m2, complex, immune evasion, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Monkeypox virus; More
• Total number of polymer chains: 14
• Total formula weight: 333941.96

Authors

Wang, Y.,Yang, S.,Zhao, H.,Deng, Z. (deposition date: 2023-01-04, release date: 2023-08-30, Last modification date: 2023-12-13)

• Primary citation: Yang, S.,Wang, Y.,Yu, F.,Cheng, R.,Zhang, Y.,Zhou, D.,Ren, X.,Deng, Z.,Zhao, H.; Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.; Nat Commun, 14:5186-5186, 2023; PubMed: 37626059; DOI: 10.1038/s41467-023-40748-2

Experimental method

ELECTRON MICROSCOPY (3.12 Å)