8HW2

Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs

Summary for 8HW2

Entry DOI	10.2210/pdb8hw2/pdb
EMDB information	35049
Descriptor	ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide (2 entities in total)
Functional Keywords	abc transporter, transport protein, multidrug resistance protein, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	170401.73
Authors	Wang, J.,Wang, F.F.,Chen, Y.X.,Zhou, C.Z. (deposition date: 2022-12-28, release date: 2023-06-07, Last modification date: 2023-10-11)
Primary citation	Wang, J.,Li, X.,Wang, F.F.,Cheng, M.T.,Mao, Y.X.,Fang, S.C.,Wang, L.,Zhou, C.Z.,Hou, W.T.,Chen, Y. Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42:e113415-e113415, 2023 Cited by PubMed: 37485728 DOI: 10.15252/embj.2022113415 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.65 Å)

Structure validation