8HUM

X-ray structure of human PPAR gamma ligand binding domain-lanifibranor-SRC1 coactivator peptide co-crystals obtained by co-crystallization

Summary for 8HUM

Entry DOI	10.2210/pdb8hum/pdb
Descriptor	Isoform 1 of Peroxisome proliferator-activated receptor gamma, 15-meric peptide from Nuclear receptor coactivator 1, 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid, ... (4 entities in total)
Functional Keywords	nuclear receptor, protein-ligand complex, ppar, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	34146.09
Authors	Kamata, S.,Honda, A.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Masuda, R.,Oyama, T.,Ishii, I. (deposition date: 2022-12-24, release date: 2023-08-09, Last modification date: 2023-09-06)
Primary citation	Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12:-, 2023 Cited by PubMed: 37627519 DOI: 10.3390/antiox12081523 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation