8HUK
X-ray structure of human PPAR alpha ligand binding domain-lanifibranor-SRC1 coactivator peptide co-crystals obtained by soaking
Summary for 8HUK
Entry DOI | 10.2210/pdb8huk/pdb |
Descriptor | Peroxisome proliferator-activated receptor alpha, 15-meric peptide from Nuclear receptor coactivator 1, 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid (3 entities in total) |
Functional Keywords | nuclear receptor, protein-ligand complex, ppar, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 63995.20 |
Authors | Kamata, S.,Ishikawa, R.,Akahane, M.,Honda, A.,Oyama, T.,Ishii, I. (deposition date: 2022-12-24, release date: 2023-08-09, Last modification date: 2023-09-06) |
Primary citation | Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants, 12:-, 2023 Cited by PubMed: 37627519DOI: 10.3390/antiox12081523 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.981 Å) |
Structure validation
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