8HTB

Staphylococcus aureus FtsZ 12-316 complexed with TXH9179

Summary for 8HTB

Entry DOI	10.2210/pdb8htb/pdb
Descriptor	Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... (5 entities in total)
Functional Keywords	gtpase, protein-inhibitor complex, antibacterial agent, hydrolase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	32681.63
Authors	Bryan, E.,Ferrer-Gonzalez, E.,Sagong, H.Y.,Fujita, J.,Mark, L.,Kaul, M.,LaVoie, E.J.,Matsumura, H.,Pilch, D.S. (deposition date: 2022-12-21, release date: 2023-09-20)
Primary citation	Bryan, E.,Ferrer-Gonzalez, E.,Sagong, H.Y.,Fujita, J.,Mark, L.,Kaul, M.,LaVoie, E.J.,Matsumura, H.,Pilch, D.S. Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus. Acs Chem.Biol., 18:629-642, 2023 Cited by PubMed: 36854145 DOI: 10.1021/acschembio.2c00934 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation