8HOY

Cryo-EM structure of monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex without DNA at 2.76 angostram

Summary for 8HOY

Entry DOI	10.2210/pdb8hoy/pdb
EMDB information	34684 34927
Descriptor	DNA polymerase, DNA polymerase processivity factor component A20, E4R (3 entities in total)
Functional Keywords	dna replication machinery, dna polymerase, b-family dna polymerase, uracil-dna glycosylase, mpxv, orthopoxvirus, poxviridae, dna processivity factor, viral protein
Biological source	Monkeypox virus More
Total number of polymer chains	3
Total formula weight	197128.79
Authors	Xu, Y.,Wu, Y.,Zhang, Y.,Fan, R.,Yang, Y.,Li, D.,Yang, B.,Zhang, Z.,Dong, C. (deposition date: 2022-12-11, release date: 2023-12-13, Last modification date: 2025-07-02)
Primary citation	Xu, Y.,Wu, Y.,Zhang, Y.,Fan, R.,Yang, Y.,Li, D.,Zhu, S.,Yang, B.,Zhang, Z.,Dong, C. Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex. Cell Res., 33:479-482, 2023 Cited by PubMed: 36973539 DOI: 10.1038/s41422-023-00796-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.76 Å)

Structure validation