8HLT

The co-crystal structure of DYRK2 with YK-2-99B

8HLT の概要

• エントリーDOI: 10.2210/pdb8hlt/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, (6-{[(4P)-4-(1,3-benzothiazol-5-yl)-5-fluoropyrimidin-2-yl]amino}pyridin-3-yl)(piperazin-1-yl)methanone (2 entities in total)
• 機能のキーワード: inhibitor, cell cycle
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 91387.48

構造登録者

Shen, H.T.,Xiao, Y.B.,Yuan, K.,Yang, P.,Li, Q.N. (登録日: 2022-12-01, 公開日: 2023-12-13)

• 主引用文献: Yuan, K.,Shen, H.,Zheng, M.,Xia, F.,Li, Q.,Chen, W.,Ji, M.,Yang, H.,Zhuang, X.,Cai, Z.,Min, W.,Wang, X.,Xiao, Y.,Yang, P.; Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.; J.Med.Chem., 66:4215-4230, 2023; PubMed: 36800260; DOI: 10.1021/acs.jmedchem.3c00106

実験手法

X-RAY DIFFRACTION (2.8 Å)