8HJT

Crystal Structure of Intracellular B30.2 Domain of VpBTN3 and VpBTN2 in Complex with HMBPP

Summary for 8HJT

• Entry DOI: 10.2210/pdb8hjt/pdb
• Descriptor: butyrophilin subfamily 2 member A2, Butyrophylin 3, (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, ... (5 entities in total)
• Functional Keywords: butyrophilin, signaling protein, immune system
• Biological source: Vicugna pacos (alpaca); More
• Total number of polymer chains: 4
• Total formula weight: 98572.78

Authors

Yang, Y.Y.,Shen, P.P.,Li, X.,Yi, S.M.,Zhang, M.T.,Huang, J.-W.,Chen, C.-C.,Guo, R.-T. (deposition date: 2022-11-23, release date: 2023-09-13, Last modification date: 2023-10-18)

• Primary citation: Yuan, L.,Ma, X.,Yang, Y.,Qu, Y.,Li, X.,Zhu, X.,Ma, W.,Duan, J.,Xue, J.,Yang, H.,Huang, J.W.,Yi, S.,Zhang, M.,Cai, N.,Zhang, L.,Ding, Q.,Lai, K.,Liu, C.,Zhang, L.,Liu, X.,Yao, Y.,Zhou, S.,Li, X.,Shen, P.,Chang, Q.,Malwal, S.R.,He, Y.,Li, W.,Chen, C.,Chen, C.C.,Oldfield, E.,Guo, R.T.,Zhang, Y.; Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate V gamma 9V delta 2 T cells.; Nature, 621:840-848, 2023; PubMed: 37674084; DOI: 10.1038/s41586-023-06525-3

Experimental method

X-RAY DIFFRACTION (2.91 Å)