8HJE
Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28
Summary for 8HJE
Entry DOI | 10.2210/pdb8hje/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 28, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide (2 entities in total) |
Functional Keywords | vismodegib, usp28, catalytical domain, inhibitor, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 44853.82 |
Authors | |
Primary citation | Zhou, D.,Xu, Z.,Huang, Y.,Wang, H.,Zhu, X.,Zhang, W.,Song, W.,Gao, T.,Liu, T.,Wang, M.,Shi, L.,Zhang, N.,Xiong, B. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur.J.Med.Chem., 254:115369-115369, 2023 Cited by PubMed: 37075624DOI: 10.1016/j.ejmech.2023.115369 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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